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Zahra Khorrami,¹ Koorosh Etemad,¹ Shahin Yarahmadi,² Soheila Khodakarim,¹ Mohammadesmail Kameli,³ Alireza Mahdavi Hezaveh ⁴ and Ebrahim Rahimi ^1,5

التحضُّر وعوامل الخطر المتعلقة بالأمراض غير السارية: ترصد عوامل الخطر المتعلقة بالأمراض غير السارية في إيران في 2011 وفقاً للنهج المتدّرج لمنظمة الصحة العالمية

زهرا خرمى، كورش اعتماد، شهين يارا أحمدي، سهيلا خداكريم، محمد إسماعيل كاملي ، عليرضا مهدودي هزاوه، ابراهيم رحيمي

الخلاصة: أجريت هذه الدراسة للنظر في العلاقة بين التحضر وعوامل الخطر المرتبطة بالأمراض غير السارية وفقاً للنهج المتدرّج لمنظمة الصحة العالمية لمراقبة الأمراض غير السارية. وتأتي هذه الدراسة ضمن عملية ترصد عوامل الخطر المرتبطة بالأمراض غير السارية لما مجموعه 10,069 شخصاً في جميع محافظات جمهورية إيران الإسلامية، في الفئة العمرية فوق 20 عاماً، خلال عام 2011. وباستخدام بيانات التعداد السكاني لعام 2011، حددت مستويات التحضر في جميع المحافظات واستخدم الانحدار اللوجستي لدراسة العلاقة بين التحضر وعوامل الخطر. وفي صفوف الذكور، ظهر ارتباط موجب بين التحضر وانخفاض النشاط البدني

(OR=1.7, CI %95 = 1.42 – 2.09)، وانخفاض معدل استهلاك الفاكهة والخضر (OR=1.8, CI %95 = 1.09 – 2.96)، وارتفاع مؤشر كتلة الجسم (aOR=1.4; CI %95 = 1.20 – 1.70). أما في صفوف الإناث، فسُجِّل ارتباط موجب وذو دلالة بين التحضر وانخفاض النشاط البدني (OR=1.2; CI = %95 = 1.08 – 1.49)، وانخفاض معدل استهلاك الفاكهة والخضر (OR=1.3; CI %95 = 1.14 – 1.53)، وارتفاع مؤشر كتلة الجسم (OR=1.22; CI %95 = 0.78 – 1.91). ومن ثمَّ، يتضح أن التحضر يرتبط ارتباطاً ذا دلالة مع زيادة عوامل الخطر المرتبطة بالأمراض غير السارية في جمهورية إيران الإسلامية.

ABSTRACT This study was conducted to examine the relationship between urbanization and risk factors of noncommunicable diseases (NCDs) according to the World Health Organization stepwise approach to surveillance of NCDs. This study is part of a NCD risk factor surveillance of 10 069 individuals in all provinces of the Islamic Republic of Iran, aged over 20 years, during 2011. By utilizing 2011 census data, urbanization levels were determined in all provinces and logistics regression was used to examine the relationship between urbanization and risk factors. Among males, urbanization had a positive correlation with low physical activity (OR=1.7; 95% CI: 1.42-2.09), low fruit and vegetable consumption (OR=1.8; 95% CI: 1.09-2.96), and high BMI (OR=1.4; 95% CI: 1.20-1.70). Among females there was a positive and significant correlation with low physical activity (OR=1.2; 95% CI: 1.08-1.49), low fruit and vegetable consumption (OR=1.22; 95% CI: 0.78-1.91) and high BMI (OR=1.3; 95% CI: 1.14-1.53). Thus, urbanization has a significant correlation with increases in NCD factors in the Islamic Republic of Iran.

Urbanisation et facteurs de risque de maladies non transmissibles (MNT) : approche STEPwise de l’OMS pour la surveillance des facteurs de risque de MNT en République islamique d’Iran en 2011

RÉSUMÉ La présente étude a été menée afin d’examiner la relation entre l’urbanisation et les facteurs de risque de MNT, selon le modèle de l’approche STEPwise de l’OMS pour la surveillance des maladies non transmissibles. L’étude s’inscrit dans la surveillance des facteurs de risque de MNT opérée sur 10 069 personnes âgées de plus de 20 ans dans l’ensemble des provinces de la République islamique d’Iran en 2011. À l’aide de données du recensement de 2011, les niveaux d’urbanisation ont pu être déterminés pour toutes les provinces, et la régression logistique a été utilisée afin d’examiner la relation entre l’urbanisation et les facteurs de risque. Parmi les hommes, l’urbanisation avait une corrélation positive avec une faible activité physique (OR = 1,7, IC à 95 % : 1,42-2,09), une faible consommation de fruits et légumes (OR = 1,8, IC à 95 % : 1,09-2,96) et un indice de masse corporelle élevé (OR = 1,4, IC à 95 % : 1,20-1,70). Parmi les femmes, il existait une corrélation positive et significative avec une faible activité physique (OR = 1,2, IC à 95 % : 1,08-1,49), une faible consommation de fruits et légumes (OR = 1,22, IC à 95 % : 0,78-1,91) et un indice de masse corporelle élevé (OR = 1,3, IC à 95 % : 1,14-1,53). L’urbanisation a donc une corrélation significative avec l’augmentation des facteurs de MNT en République islamique d’Iran.

¹Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran (Correspondence to: Koorosh Etemad: This e-mail address is being protected from spambots. You need JavaScript enabled to view it ). ²Endocrine and Metabolic Office; ³Office of Hospital Management and Clinical Service Excellence; ⁴Diabetes Control and Prevention Program, Center for Noncommunicable Diseases Control, Ministry of Health & Medical Education, Tehran, Islamic Republic of Iran; ⁵Department of Epidemiology, Mamasani Higher Education Complex for Health, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.

Received: 13/01/16; accepted: 16/11/16

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Introduction

It has been predicted that over 60% of the world population in low- and middle-income countries will be living in cities by 2030 (1). Certain lifestyle and environmental factors related to urbanization have a significant effect on health and noncommunicable diseases (NCDs). Urbanization is one of the main socioenvironmental factors which has a relationship with changing lifestyles as an important risk factor for NCDs (2). Previous research in low- and middle-income countries has indicated that NCD risk factors are more common in urban than in rural areas (3). In recent years, the increase in NCDs has been a common concern as a major cause of morbidity and mortality worldwide (4). It has been estimated that 33 million deaths in 2008 were due to NCDs, and this is predicted to reach 52 million by 2030 (5). Urbanization has an association with lifestyle and behavioural risk factors such as unhealthy diet and low physical activity (6–8). Evidence from South-East Asia has indicated that urbanization has a is associated with NCD risk factors such as low physical activity, unhealthy diet, overweight and high blood pressure (9,10). In the past few decades, traditional communities in low- and middle-income countries have experienced rapid, unplanned urbanization, which changed lifestyles and resulted in unhealthy diets, a sedentary lifestyle and smoking (11). In the past, urban and rural environments were significantly different; however, the distinction is less clear now due to recent advances (12). Many definitions of urbanization only use the simple dichotomous variable of urban and rural, making it difficult to understand the specific changes within the urbanization process that have led to changes in the main risk factors for NCDs (13).

In recent years, there has been a rapid change in lifestyle and demographic and socioeconomic status in the Iranian community due to the escalation in urbanization and industrialization. The aim of this study was to investigate the association between urbanization and the risk factors for NCDs, which may lead to the identification of new, more effective interventions in the prevention of chronic diseases.

Method

Study population and sampling

We assessed the association between urbanization and NCD risk factors using the data from the 2011 survey of NCD risk factor surveillance (STEPS) conducted by the Ministry of Health and Medical Education in the 31 provinces of the Islamic Republic of Iran (14). The study population was 10 069 people aged 20–70 years. A multistage random cluster sampling method with probability proportional to size sampling was used.

Measuring urbanization

Principal component analysis is a multivariate statistical method to reduce the number of variables (15). This method was used to create the urbanization variable; overall score is based on the score obtained using the xtile quint command in SPSS (percentiles of 33.3 and 66.7) in 3 categories low, medium and high.

There is no global standard indicator to measure urbanization because the factors associated with urbanization in one region of a country are different from those of others countries. From analysis of previous studies, the indices that had the greatest effect on urbanization were identified and included in this study (13,16,17). Data on 24 variables measuring multiple aspects of urbanization (e.g. demographic and socioeconomic indices, human resources, communication, energy, the human development index for the province, and health and treatment indicators) were used to extract their underlying constructs. The principal components analysis-based index is a simple and robust measure whose values and groupings can only be moderately affected by changes in the urbanization landscapes. This multivariate statistical technique is used to reduce the number of variables in a data set into a smaller number of “dimensions” that are linear combinations of the original variables. Principal components analysis provides an objective way of aggregating the indicators so that variation in the data can be accounted for as concisely as possible. The urbanization index for all 31 provinces was calculated using this method and every province was classified into 3 urbanization levels. Variables such as average household size, population density, urbanization rate, average floor area of the dwelling unit per family member, economic participation rate, unemployment rate, employment in agriculture and industry, internet penetration, telephone and mobile penetration rate, percentage of villages with telephone communication, gas and electricity energy use per 1000 population, percentage of cities and rural areas with gas facilities, proportion of physicians per 1000 population, proportion of nurses per 1000 population, proportion of specialist physicians per 1000 population, and the human development index for each province were included in the analysis.

Risk factors

The data from the first and second stages of the 6th survey of risk factors for NCDs in 2011 in the Islamic Republic of Iran were used in this study (14). The NCD risk factors suggested by WHO such as demographic (residential location, age, gender, education, and job), nutrition (fruit and vegetable consumption), behavioural (smoking and physical activity), and anthropometric and blood pressure measurements were used in this survey. Anthropometric measurements include height, weight and body mass index (BMI) as an indicator of obesity. Blood pressure was measured 3 times at 3 minute intervals in a sitting position using an Omron electronic sphygmomanometer with an accuracy of 1 mmHg. Smoking was defined as daily cigarette and/or water-pipe consumption, low fruit and vegetable consumption as  90 mmHg (16).

Outcome variable

We calculated the risk factor prevalence for each outcome within each level of urbanization. In addition, we investigated the relationship between risk factor and level of urbanization. Following WHO guidelines (19), we calculated the average consumption unit of fruits and vegetables a day, BMI, systolic and diastolic blood pressure, and age of starting smoking.

Statistical methods

The principal components analysis method was used to calculate the urbanization variable. Descriptive analysis was reported using descriptive statistics for every level of urbanization. The Kolmogorov–Smirnov test was utilized to assess the normality of variables. The 2-way Kruskal–Wallis test was used to assess the association between every continuous exposure variable and level of urbanization. Binary logistic regression analysis was used to explore the association between NCD risk factors and urbanization level. P-value < 0.05 was considered significant, and SPSS, version 21, was used for all computations.

Results

Urbanization index

Urbanization scores ranged from –1.34 to 3.83 (Table 1). These were divided based on the scores obtained from xtile quint command (percentile of 33.3 and 66.7) into 3 categories: low, medium and high. Table 1 shows the distribution of provinces according to urbanization index. In the principal components analysis, variables such as internet penetration and provincial human development index achieved the greatest weight in comparison with other variables related to urbanization.

Demographic characteristics

The study population was aged 20–70 [overall mean 43.00 (standard deviation 15.34)] years (Table 2). Individual education levels were higher with greater urbanization: 35.7% of those living in areas of low urbanization were illiterate while only 20.2% of those living in areas of high urbanization were illiterate. There was also a significant difference in terms of employment among different urbanization levels (P < 0.05) (Table 2).

Urbanization and noncommunicable disease risk factors

Tobacco

The prevalence of smoking among men was similar in all 3 urbanization levels (Table 3). In univariate logistic regression analysis, there was no significant association between smoking and urbanization among men (OR = 1.02, 95% CI: 0.84–1.24 for medium and OR = 0.90, 95% CI: 0.74–1.10 for high versus low levels of urbanization) or women (OR = 0.70, 95% CI: 0.50–0.99 for medium and OR = 0.85, 95% CI: 0.61–1.19 for high versus low levels of urbanization) (Table 4). In multiple logistic regression analysis after adjustment for age, there was still no significant association between smoking and urbanization in men and women. Among those living in higher levels of urbanization, the average age of starting smoking was lower in both sexes, and smoking was more prevalent among women (Figure 1A).

Low physical activity

Urbanization had an inverse association with physical activity in both sexes: the prevalence of low physical activity increased significantly with increased urbanization (Table 3). In multiple logistic regression analysis after adjustment for age, there was a statistically significant association between low physical activity and urbanization in men (OR = 1.58, 95% CI: 1.30–1.91 for medium and OR = 1.72, 95% CI: 1.42–2.09 for high versus low levels of urbanization) and women (OR = 1.36, 95% CI: 1.15–1.60 for medium and OR = 1.26, 95% CI: 1.08–1.49 for high versus low levels of urbanization) (Table 4).

Low fruit and vegetable consumption

In both sexes, the prevalence of low fruit and vegetable consumption increased with increased urbanization, but this was significant only for men (Table 3). With increasing urbanization, the odds of low consumption of fruits and vegetables increased. Men who were living in provinces with a medium level of urbanization were 2.10 times more likely (crude OR = 2.10, 95%CI: 1.26–3.48) and those living in provinces with a high level of urbanization 1.81 times more likely (crude OR = 1.81, 95%CI: 1.10–2.98) to have low fruit and vegetable consumption in comparison with those living in areas with a low level of urbanization. This association did not change after adjustment for age in multiple logistic regression. This positive relationship was also seen in women, but it was not statistically significant (Table 4). We also found a small difference between the mean servings of fruits and vegetables consumed per day for both sexes at different levels of urbanization (P < 0.05) (Table 5 and Figure 1B).

High body mass index

The prevalence of higher BMI levels (obese and overweight) in both sexes was positively related to increased urbanization (Table 3). The odds of men having high BMI levels in medium and high levels of urbanization were 1.18 (crude OR = 1.18, 95% CI: 0.99–1.40) and 1.44 (crude OR = 1.44, 95% CI: 1.21–1.71) in comparison with lower levels of urbanization (Table 4). There was also a significant association between high BMI and urbanization in women (OR = 1.21, 95% CI: 1.05–1.29 for medium and OR = 1.30, 95% CI: 1.13–1.50 for high versus low levels of urbanization). These associations did not change after adjustment for age in multiple logistic regressions. Moreover, a statistically significant association was observed between urbanization and mean BMI in both sexes as a continuous variable (P < 0.001) (Table 5 and Figure 1C).

High blood pressure

A higher prevalence of high blood pressure was observed in areas with medium levels compared with areas with low levels of urbanization for both sexes (Table 3). The same observation was not seen for areas with high levels of urbanization. In univariate logistic regression analysis, there was a significant association between high blood pressure and urbanization in men (OR = 1.25, 95% CI: 1.00–1.57) for medium versus low levels of urbanization and women for medium (OR = 1.29, 95% CI: 1.08–1.54) and for high (OR = 0.78, 95% CI: 0.64–0.94) versus low levels of urbanization. This association did not change after adjustment for age in multiple logistic regression (Table 4). In addition, using the Kruskal–Wallis test, mean systolic and diastolic blood pressure had a significant association with level of urbanization in both sexes (P < 0.001) (Table 5 and Figures 1D and 1E).

Discussion

Our findings support the hypothesis that there is a relationship between urbanization and NCD risk factors: urbanization had a positive association with low physical activity, low intake of fruit and vegetables, BMI and hypertension in both sexes. In 2009, a study conducted in the Islamic Republic of Iran reported a relationship between urbanization and risk factors of NCD, such that prevalence of NCD risk factors increased with increasing urbanization, consistent with our findings (20). A study conducted in India indicated that there was a relationship between smoking and urbanization in men (21). In our study, however, no such significant association was observed. Nevertheless, the results showed that with increasing urbanization the age of starting smoking decreased; this relationship was more evident in women, suggesting that preventive measures should be taken along with education about the dangers and side-effects of smoking in high-risk groups. In Qingdao, China, researchers found that urbanization was related to a number of risk factors such as low physical activity, unhealthy diet and obesity (21), consistent with the results of this study. Liu et al. found that urban development significantly reduced daily physical activity and increased the consumption of high calorie foods (fast food) (22). It has consequently led to a rapid increase in obesity and overweight due to changes in diet and lifestyle which significantly affect health (12,23,24). A study from India showed no significant relationship between the prevalence of low fruit and vegetable consumption and different levels of urbanization in either sex (16). Unlike the Indian study, we found significant differences in the prevalence of low fruit and vegetable consumption among different levels of urbanization before and after age-adjusted analyses. In a study conducted in Greenland, no relationship was found between unhealthy dietary patterns and urbanization or socioeconomic status (25). In a study in 100 countries, Ezzati et al. found that BMI increased with increasing urbanization (26). Our findings indicate that with increasing urbanization, average BMI, high blood pressure, and low physical activity increased, consistent with previous studies (27–29). We found the prevalence of physical activity was higher in areas with low urbanization than in areas with high urbanization, consistent with the results of other studies (30,31). In a study in Sri Lanka, men and women in areas with high urbanization had respectively 3 and 2 times lower physical activity than those living in other urban areas, which was significant after age adjustment (32). Monda et al. also found that low physical activity increased with increasing urbanization (33). Our findings are consistent with those of other studies in that as a result of office jobs in the city and the use of technology, physical activity is reduced and the city population has a sedentary rather than an active lifestyle. Therefore, it is suggested that in areas with high levels of urbanization, the focus should be on environmental characteristics and providing facilities such as trails, parks, swimming pools, and gyms. Walking teams, teams for beautifying green spaces, and increasing street lighting are effective in increasing physical activity (32,33). In some studies, the likelihood of having high blood pressure was greater for residents of areas with high urbanization than for residents of other areas, after age adjustment (26,29,30,34). Mathenge et al. found that likelihood of having hypertension was greater in urban residents than in rural residents after age and sex adjustment (27). A 2015 Chinese study concluded that environmental changes have a potential impact on systolic and diastolic blood pressure (35). Increased prevalence of high blood pressure can be attributed to increased environmental risk factors parallel to increased urbanization, while globally, high blood pressure is one of the risk factors associated with number of deaths (36).

Our study has a cross-sectional nature, and thus no causality association can be deduced from it. In terms of the scale of urbanization, 2 provinces can have the same urbanization level, but may differ in other environmental dimensions that are likely to differentially affect health. Thus, more environmental research is needed to understand the implications of urbanizing the environment to develop an exposure measure for NCDs. Moreover, possible differences in factors probably caused by urbanization, such as stress levels and environmental factors, were not investigated; these could be considered valid for future population studies. Further development is required to understand the relative contribution of internet penetration, human development index, and each scale element for risk of chronic diseases. As self-reported information was received from participants regarding nutrition (fruit and vegetable consumption) and behavioural factors (smoking and physical activity), there is the possibility that information bias may have affected the results.

Our findings indicate that increasing urbanization is related to the increased prevalence of several modifiable NCD risk factors that couldn serve as a basis for future studies, planning in order to manage health problems, determining the distribution of financial resources and human resources, and coordinating prevention and intervention strategies for NCDs based on different levels of urbanization.

Conclusion

In this study, urbanization was described and classified using different factors instead of the known rural/urban dichotomy, and a clear association was observed between different levels of urbanization and NCD risk factors. Increasing urbanization and its consequent complications requires policies and preparations by local governments to meet the needs of the community, which requires an intersectoral agreement and cooperation with other academic and administrative sectors.

Funding: This study was part of the MSc thesis of Zahra Khorrami, supported by Shahid Beheshti University of Medical Sciences (grant No.: /A/9294/36).

Competing interests: None declared.

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