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A.R. Charkazi,¹ G. Kouchaki,² M. Soleymani Nejad ¹ and A.H. Gholizade ³

معارف الأطباء المقيمين عن السل واستـراتيجية المعالجة القصيرة الأمد تحت الإشراف المباشر في شرق جمهورية إيران الإسلامية

عبد الرحمن جركزي، قربان محمد كوجكي، مرضية سليمان نزاد، قلي زاده عبد الهادي

الخلاصـة: يُعَدُّ المعدَّل المتزايد لوقوع السل من الشواغل الرئيسية لدى أصحاب القرار السياسي في الصحة العمومية. وقد صمَّم الباحثون استبياناً حول الدلائل الإرشادية الخاصة ببرنامج مكافحة السل، بهدف تقييم معارف طلاب الطب حول هذا المرض وحول استـراتيجية المعالجة القصيرة الأمد تحت الإشراف المباشر في منطقة ذات معدَّل مرتفع لوقوع السل في جمهورية إيران الإسلامية، وأعطيت الاستبيانات لثمانين من الأطباء المقيمين في كليتَيْ الطب في كُلستان ومازنداران في كانون الأول/ديسمبر 2007. وقد بلغت الأحراز الإجمالية الصحيحة الوسطية 1.80 بنداً (بانحراف معياري 1.61) من أصل 15 على سلم المعارف. وكانت المعارف حول التشخيص والمعالجة والرَّصْد بالغة السوء بشكل خاص. ولم يكن هناك فروق يُعْتَدُّ بها إحصائياً بين معارف الأطباء المقيمين الذين استكملوا فتـرة إقامتهم في أقسام الأمراض المعدية أو صحة المجتمع وبين معارف الأطباء المقيمين الذين لم يستكملوها.

ABSTRACT The increasing incidence of tuberculosis (TB) is a major concern to public health policy-makers. To assess knowledge about TB and the DOTS strategy among medical students in a high incidence area of the Islamic Republic of Iran, a questionnaire designed around the national TB programme guidelines was given to 80 interns in Golestan and Mazandaran medical schools in December 2007. The overall mean knowledge score was 1.80 (SD 1.61) items correct out of 15. Knowledge about diagnosis, treatment and monitoring was especially poor. There were no significant differences between the knowledge of interns who had completed their internships in the infectious diseases or community health departments compared with those who had not.

Connaissances des internes en médecine sur la tuberculose et sur la stratégie du traitement de durée brève sous surveillance directe dans la partie septentrionale de la République islamique d’Iran

RÉSUMÉ L’incidence croissante de la tuberculose est une préoccupation majeure pour les responsables politiques de la santé publique. Pour évaluer les connaissances des étudiants en médecine sur la tuberculose et sur la stratégie du traitement de durée brève sous surveillance directe dans une zone d’incidence élevée de la République islamique d’Iran, un questionnaire élaboré à partir des directives nationales du programme de lutte contre la tuberculose a été administré à 80 internes des facultés de médecine de Golestan et Mazandaran, en décembre 2007. Le score moyen global était d’1,80 réponse exacte (E.T. 1,61) sur un total de 15 questions. Les connaissances concernant le diagnostic, le traitement et le suivi étaient particulièrement insuffisantes. Il n’y avait pas de différences significatives entre les connaissances des internes qui avaient effectué leur internat dans le service des maladies infectieuses ou dans les services de santé communautaires et les connaissances des internes d’autres services.

¹Department of Public Health; ²Department of Surgery, School of Paramedicine and Health, Golestan University of Medical Sciences, Gorgan, Islamic Republic of Iran (Correspondence to A.R. Charkazi: This e-mail address is being protected from spambots. You need JavaScript enabled to view it ).

³Department of Public Health, School of Health, Mazandaran University of Medical Sciences, Sari, Islamic Republic of Iran.

Received: 09/02/09; accepted: 20/05/09

EMHJ, 2010, 16(12): 1251-1256

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Introduction

The increasing incidence of tuberculosis (TB) is a major concern to public health policy-makers in both developing and developed countries [1–3]. Approximately one-third of the world’s population is infected with Mycobacterium tuberculosis, and 3 million people die every year due to TB [4]. Today, in spite of M. tuberculosis screening, vaccines and effective anti-TB drugs, it is still a major global public health problem [5,6]. Incorrect and insufficient treatment, the emergence of multi-drug resistant (MDR-TB) strains and the co-epidemic with HIV all contributed to the failure of TB control, prompting the World Health Organization (WHO) to pronounce TB a global emergency in 1993 [1].

In the Islamic Republic of Iran the incidence of TB decreased steadily from 34 per 100 000 population in 1993 to 13.2 per 100 000 population in 2006, after the introduction of the WHO recommended TB control strategy known as directly-observed treatment short-course (DOTS). In several regions such as Sistan va Baluchistan and Golestan provinces the incidence of TB is higher than in other regions [7]. Medical interns, as future specialist and general physicians (GPs), are the backbone of any health care system and are in a position to make an impact on TB control. Nevertheless, there is limited data about knowledge of TB and the DOTS strategy among medical interns. Previous studies conducted in the Islamic Republic of Iran showed poor knowledge about TB and DOTS among GPs in the public and private health sectors [8–10].

In view of the importance of physicians’ collaboration in TB care to achieve control of the disease, we designed this study to evaluate knowledge of TB control and its management via the DOTS strategy among the medical interns of Golestan and Mazandaran medical schools in the northern part of the Islamic Republic of Iran.

Methods

A cross-sectional study was carried out in December 2007, simultaneously among interns of Golestan University of Medical Sciences in Gorgan city and Mazandaran University of Medical Sciences in Sari city.

Participants

To recruit participants for the study, a list of all interns resident in 7 hospitals (4 in Sari and 3 in Gorgan) were obtained from the medical schools. All departments and wards in the hospitals were visited to recruit the students to the study. Of the 103 eligible students 23 dropped out (15 in Gorgan and 8 in Sari), giving a final sample of 80 students. Interns gave verbal consent to participate after being given assurances of confidentiality and anonymity. A repeat visit was conducted on the subsequent 3 days to include interns who were absent during the first visit or could not be contacted as they were off-duty or busy at the time.

Data collection

Data were gathered using a self-administered questionnaire with a mix of open- and closed-ended questions. The first section recorded some background information (age, sex, university and whether they had completed internships in departments where the subject of TB is taught routinely). The second section assessed TB knowledge based on the DOTS strategy including: meaning of the acronym DOTS, description of the DOTS concept, meaning of the term MDR-TB, usual mode of transmission of TB, most common symptoms of pulmonary TB, the best tests for diagnosis of pulmonary TB and for monitoring of treatment, categories of TB treatment, the recommended anti-TB regimen in the initial and continuous phases, definition of failure of TB treatment, criterion for a cured person and the types of TB that need long-term treatment.

The questionnaire was designed using the national tuberculosis programme guidelines and its validity was determined by assessing its content validity and testing its reliability by test–retest (r = 0.85).

Statistics

All data were entered into SPSS, version 13 for Windows, and double entry of data was used in order to check for data entry accuracy. Independent t-tests were performed to analyse any differences in mean knowledge. Values of P ≤ 0.05 were considered significant. All other measures were subject to descriptive statistics. Interns’ knowledge level was described as high if they scored > 75% correct answers, moderate if 50%–75% correct or low if < 50% correct.

Results

Background data of participants

The participants comprised 44 (55%) men and 36 (45%) women. Their mean [standard deviation (SD)] age was 25.8 (SD 1.5) years, range 24–31 years. Of these, 28.8% had completed their internship in the infectious diseases ward and 27.5% in the community health department. The participants’ demographic characteristics are shown in Table 1.

DOTS strategy and MDR-TB

Over 90% of the participants were unable to define the DOTS acronym and 83.8% could not describe the DOTS concept; 57.5% were unable to define the term MDR-TB (Table 2).

Transmission and symptoms

A majority of interns (85.0%) correctly identified TB as a droplet infection, while some thought that sexual intercourse (8.7%) and digestion (5.0%) were routes of transmission (Table 3).

Two-fifths (40.0%) mentioned coughing for 3 weeks or more as an important symptom of pulmonary TB; other answers included chest pain (20.0%), dyspnoea (15.0%) and haemoptysis (12.5%) (Table 3).

Diagnosis and follow-up

Only 17.5% considered sputum smears for acid-fast bacilli (AFB) as the best test for diagnosis of pulmonary TB, while 60.0% proposed chest X-ray (Table 3). Only 6.3% considered sputum microscopy as the best test for follow-up of cases under treatment, while 85.0% thought it was chest X-ray.

Treatment and management

Only a few participants (7.5%) were able to define categories of TB treatment and duration of consumption of drugs in 2 categories (Table 4). Four-fifths (80.0%) were unable to recommended which anti-TB drugs should be used in each category. Asked to name the 4 types of TB that need long-term chemotherapy (miliary, CNS, meningeal and skeletal TB), 58.8% could not identify even 1 type. Very few knew how to define TB treatment failure and only 2 respondents were able to give the definition of a cured case of TB.

Knowledge assessment

The overall mean knowledge score for the 80 interns was 1.80 (SD 1.61) correct answers from a maximum of 15. Knowledge of all interns was poor: none of them achieved a moderate or high score. There was no significant difference between the knowledge of interns who had completed their internships in the infectious diseases or community health departments and those who had not (data not shown).

Discussion

In this study interns working in 7 medical centres in Gorgan and Sari had very weak knowledge of TB. Our results are consistent with the findings of studies in other regions and countries such as those of Shehzadi [11], Khan [12], Harries [13], Lotfi [8], Nojoomi [9] and Talaeei [10], in which most interns and GPs had insufficient knowledge. Our study also showed that poor knowledge of TB among interns was not affected by the type of ward they had worked in. Students who had completed their internships in the infectious diseases and community health departments, where the subject of TB is taught routinely, had no better knowledge than those who had no experience in these fields.

Our findings about knowledge of transmission of M. tuberculosis were con sistent with studies of medical students, residents and interns in Pakistan, the United States of America and Nigeria, although subjects there were somewhat better informed, with 96%, 95% and 88.1% knowing that droplet infection was the usual mode of transmission compared with 85.0% in our study [12,14,15]. A study among GPs in Pakistan showed that only 68% correctly identified TB as a droplet infection [11]. Two studies in India and the Philippines showed poor knowledge about the mode of transmission, with about 4% of interns and 21% of physicians aware that droplet infection was the only route of transmission [16,17].

Cough for 3 weeks or more is considered to be the primary symptom of pulmonary TB according to WHO guidelines. Two-fifths of interns in our study were able to identify this symptom, although in a high prevalence region such as Golestan province this rate of knowledge was inadequate and should be higher. In contrast, in India, Pakistan, the Philippines and Somalia, physicians and medical interns were very knowledgeable about the presenting symptoms of pulmonary TB [16–19].

We found that few interns indicated sputum smear microscopy for diagnosis of TB or as a follow-up test. Sputum microscopy has a high specificity and low rate of false negatives. It is considered to be the most efficient method for diagnosis of pulmonary TB, and is advocated under the DOTS strategy worldwide. Interns in Pakistan and India were somewhat better informed about sputum smear microscopy [12,16]. Studies performed in other parts of world showed students’ and physicians’ knowledge ranging from 38% to 85% [12,14,19–23].

The interns had poor knowledge regarding treatment monitoring: a mere 6.3% were aware of AFB sputum microscopy as a monitoring tool. Their counterparts in Pakistan were better informed with 43.5% aware [12]. A study in Ethiopia revealed similar levels of knowledge among physicians [24]. However, in a study of actual practices in Pakistan, no sputum smear tests were conducted during treatment [25].

A large proportion of our interns were unfamiliar with appropriate treatment regimens in the initial and continuation phases of the national tuberculosis control programme, which is based on WHO guidelines. Almost none of the respondents knew the meaning of the DOTS acronym. Their counterparts in Pakistan were slightly better informed with about 18% able to define it [12]. Similarly, most of the students in our study were unable to define the basic concept of the DOTS strategy. When asked to write the drugs and their duration used in the initial phase (2 months of isoniazid/rifampicin/pyrazinamide/ethambutol) and the continuous phase (4 months of isoniazid/rifampicin) of treatment, only 20% of the interns were correct. This lack of knowledge about correct prescribing may lead to the spread of MDR-TB strains. In 2 surveys conducted among interns in India and Pakistan, the rates of correct knowledge of the recommended regimen were 7.8% and 56.5% respectively [12,16]. Other studies conducted in various countries about the prescribing behaviour of GPs reported similar findings [18,20,24,26,27].

The definition of treatment failure, i.e. if a patient is AFB-positive for 5 months or more after treatment begins, was correctly answered only by 13.8% of respondents. Treatment failure is a sign that the TB management and control programme is inadequate and is a risk for MDR-TB in the community.

Four types of TB need long-term treatment for 8 months: meningeal TB, miliary TB, CNS and skeletal TB. Only 1 of our participants knew all of these and 1 knew 3 types. Almost 60% abstained from responding, showing poor knowledge about this aspect of TB.

Several limitations of this study restrict the generalizability of the findings. Only 2 medical schools out of the 44 in the Islamic Republic of Iran were surveyed, and information about those who did not wish to participate was not collected.

Conclusions

In conclusion, this study demonstrated poor of knowledge about TB according to the WHO and national tuberculosis programme guidelines among interns in Sari and Gorgan in 2007. We suggest that comprehensive, updated, in-service training is needed among undergraduates, with special emphasis on the DOTS strategy, and appropriate changes in the undergraduate medical teaching curriculum. Similar studies need to be conducted in other parts of country among interns, especially in regions with a high prevalence and incidence of TB such as Sistan va Baluchistan and southern Khorasan.

Acknowledgements

This work received financial support from Golestan Medical Sciences University. We are very grateful to all interns who participated in this study and took time out of their busy lives to complete the questionnaire. We are also very thankful to Razieh Parvar, Rahimeh Arazi, Mina Kalteh and Aeazam Masoudi.

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