This publication presents guidelines that recognize the complementary nature of non-pharmacological approaches to management and pharmacotherapy and which are cost-effective. Developing skills to apply the non-pharmacological approach presents a challenge, as most doctors in our Region must be trained to be able to advise their patients on a non-pharmacological approach. Countries need a cost-effective drug management strategy that promotes adherence to medical therapy, motivates patients, builds trust and strengthens communications between clinicians and patients and their families. It is hoped that these clinical guidelines will make a positive contribution to the improved management of hypertension in the Region.