Diabetes mellitus is “a metabolic disorder of multiple etiology, characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The effects of diabetes mellitus include long-term damage, dysfunction and failure of various organs”. Thus, the metabolic abnormalities of diabetes result from inadequate insulin action on target tissues, due to deficient insulin secretion or insensitivity to insulin action, or a combination of both .